Chemical Probes logo
Apoptolidin | Apoptolidin : Inhibitor of ATP5F1B
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ATP5F1B
  • IC50:100 nM
  • EC50:5 nM
Inhibitor
10-100nM

Selectivity

In Cell Selectivity Assessment
Selectivity Assessment Description:
Apoptolidin A is a selective inhibitor of the F1 subcomplex of ATP synthase. Selectivity was assesse ...

Potency
Cellular
In Vitro

ATP5F1B

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41589-021-00900-9

Negative Control Compounds

ISOAPOPTOLIDIN
Notes: Apoptolidin A exists in equilibrium with isoapoptolidin A which does not bind to or inhibit ATP synthase. In long experiments (>4 hrs), isoapoptolidin will convert to apoptolidin which makes it better suited to short experiments (<1 hr). See PMID: 12599468, 12599467

Orthogonal Probes def

OLIGOMYCIN A
AUROVERTIN D
EFRAPEPTIN G

Chemical Information

Molecular Formula C58H96O21
SMILEs COC[C@@H](C[C@H]1O[C@@](O)([C@H](O)[C@@H]2C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C)OC1C[C@](C)(O)[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)[C@H](C)O1
InChI InChI=1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36-,37+,38+,39-,40+,41-,42-,43+,44-,45+,46+,47?,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
Molecular weight 1128.64 Da
AlogP 3.5873000000000124
HBond acceptors 21
HBond donors 8
Atoms 175

References

Publications

Cross References

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 1 Feb 2022 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria