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APAFANT | APAFANT : Antagonist of PTAFR
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
PTAFR
  • Ki:9.9 nM
  • IC50:170 nM
  • IC50:360 nM
Antagonist
use at 300 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Eurofins Safety screen (44 targets) at 10 µM [% Ctrl]: BZD/CENTR (rat) (12), PTGS2 (47); Benzodiazep ...

Potency
Cellular
In Vitro

PTAFR

Mode of Action: Antagonist

Structure-Activity-Relationship data available? No

PMID Reference: 3598913

In Vivo Validations

Rat
Dose: 11 uM/Kg
Route of delivery: Oral
Cmax: 449 nM
Tmax: 0.3 h

PMID Reference: 3598913

Negative Control Compounds

(R)-Bepafant
Notes: WEB2387: Human receptor binding Ki = 660 nM; Platelet aggregation IC50 = 8790 nM Eurofins Safety screen (44 targets) at 10 µM: clean

Chemical Information

Molecular Formula C22H22ClN5O2S
SMILEs Cc1nnc2n1-c1sc(CCC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2
InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
Molecular weight 455.12 Da
AlogP 0.0
HBond acceptors 7
HBond donors --
Atoms 53

Expert Reviews

by SERP
(on 11 Jul 2024)
In Model Organisms
The paper currently being cited for "In Vivo Validations" (i.e., PMID 3598913) highlights the following regarding the dosing of rats: "In anesthetized rats, the hypotension induced by an i.v. PAF infusion...
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