Chemical Probes logo
APAFANT | APAFANT : Antagonist of PTAFR
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PTAFR
  • Ki:9.9 nM
  • IC50:170 nM
  • IC50:360 nM
Antagonist
use at 300 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Eurofins Safety screen (44 targets) at 10 µM [% Ctrl]: BZD/CENTR (rat) (12), PTGS2 (47); Benzodiazep ...

Potency
Cellular
In Vitro

PTAFR

Mode of Action: Antagonist

Structure-Activity-Relationship data available? No

PMID Reference: 3598913

In Vivo Validations

Rat
Dose: 11 uM/Kg
Route of delivery: Oral
Cmax: 449 nM
Tmax: 0.3 h

PMID Reference: 3598913

Negative Control Compounds

BEPAFANT
Notes: WEB2387: Human receptor binding Ki = 660 nM; Platelet aggregation IC50 = 8790 nM Eurofins Safety screen (44 targets) at 10 µM: clean

Chemical Information

Molecular Formula C22H22ClN5O2S
SMILEs Cc1nnc2n1-c1sc(CCC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2
InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
Molecular weight 455.12 Da
AlogP 0.0
HBond acceptors 7
HBond donors --
Atoms 53

Expert Reviews

by SERP
(on 11 Jul 2024 )
In Model Organisms
The paper currently being cited for "In Vivo Validations" (i.e., PMID 3598913) highlights the following regarding the dosing of rats: "In anesthetized rats, the hypotension induced by an i.v. PAF infusion...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria