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AP-204 | AP-204 : Inhibitor of STK17B
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STK17B
  • IC50:130 nM
  • IC50:350 nM
Inhibitor
up to 10 µM
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selective over STK17A in NanoBRET IC50 2200 nM
In Vitro Selectivity Assessment
Potency Assay Off-Target:
DiscoverX SCANmax at 1 uM provided S10 of 0.02, total number of kinases tested 403.

Potency
Cellular
In Vitro

STK17B

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1182/blood.2025029950

In Vivo Validations

Mouse
Dose: 10 mg/Kg
Route of delivery: Oral
Plasma half life: 7.72 h
Systemic clearance: 221 mL/h/Kg
Cmax: 3.05 ug/mL
Tmax: 4.67 h
Area Under the Curve:: 47.17 ug/ml/h

DOI Reference: 10.1182/blood.2025029950

Orthogonal Probes def

OBW

Chemical Information

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References

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Expert Reviews

by SERP
(on 10 Feb 2026 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
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