AP-204

AP-204 : Inhibitor of STK17B

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe AP-204 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

STK17B

Inhibitor

up to 1 uM
Reviewer recommended concentration: up to 10 µM

In Vitro Validations

Uniprot ID: O94768

Target Class: Kinase

Target SubClass: CAMK

Potency: IC50

Potency Value: 130 nM

Potency Assay: Eurofins enzyme assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase 17B, DRAK2, STK17B ...

DOI Reference: 10.1182/blood.2025029950

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay, off target (cells): Selective over STK17A in NanoBRET IC50 2200 nM

Potency assay (off target): DiscoverX SCANmax at 1 uM provided S10 of 0.02, total number of kinases tested 403.

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

AP-204 is a optimized derivative of an earlier chemical series from the same group of researchers with improved solubility and stability.

(last updated: 10 Feb 2026 )