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AM-4668 | AM-4668 : Agonist of FFAR1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR1
    • EC50:36 nM
    • EC50:3.6 nM
    Agonist
    up to 1 uM

    Selectivity

    Potency
    Cellular
    In Vitro

    FFAR1

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/ml400501x

    In Vivo Validations

    Rat, Dog, Cyno
    Dose: 0.5 mg/Kg IP, 2 mg/Kg PO
    Route of delivery: Intravenous, Oral
    Plasma half life: 5.3 (R), 5.6 (D), 14 (C) h
    Systemic clearance: 0.09 (R), 0.15 (D), 0.04 (C) L/h/Kg

    DOI Reference: 10.1021/ml400501x

    Orthogonal Probes def

    FASIGLIFAM
    TUG-469
    AMG-837

    Chemical Information

    Molecular Formula C24H19F3N2O4S
    SMILEs Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1
    InChI InChI=1S/C24H19F3N2O4S/c1-14-21(34-23(28-14)16-2-6-17(7-3-16)24(25,26)27)13-32-18-8-4-15(5-9-18)19(12-22(30)31)20-10-11-33-29-20/h2-11,19H,12-13H2,1H3,(H,30,31)/t19-/m0/s1
    Molecular weight 488.10 Da
    AlogP 0.0
    HBond acceptors 6
    HBond donors 1
    Atoms 53

    References

    Publications

    Cross References

    canSARChEMBLBindingDB

    Vendors

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    Expert Reviews

    No SERP comments found for AM-4668

    Probe AM-4668 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.