Chemical Probes logo
alphaSyn PROTAC 2b | Degrader (PROTAC) of SNCA
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SNCA
  • Kd:1161 ± 255 nM
  • Dmax:89%
  • DC50:7510 ± 530 nM
Degrader (PROTAC)
up to 10 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Global proteomics profiling of model cells after treatment with 10 μM 2b for 24 h shows that 11 diff ...

Potency
Cellular
In Vitro

SNCA

Mode of Action: Degrader (PROTAC)

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.3c00274

Negative Control Compounds

canSAR7088058
Notes: Cells treatment with compound 2bn did not cause significant change on the level of αSyn aggregates.

Chemical Information

Molecular Formula C39H41N7O10
SMILEs O=C(CNc1cccc(-c2cc(-c3ccc4c(c3)OCO4)[nH]n2)c1)NCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChI InChI=1S/C39H41N7O10/c47-34-10-8-31(37(49)43-34)46-38(50)27-5-2-6-28(36(27)39(46)51)40-11-13-52-15-17-54-18-16-53-14-12-41-35(48)22-42-26-4-1-3-24(19-26)29-21-30(45-44-29)25-7-9-32-33(20-25)56-23-55-32/h1-7,9,19-21,31,40,42H,8,10-18,22-23H2,(H,41,48)(H,44,45)(H,43,47,49)
Molecular weight 767.29 Da
AlogP 2.5636
HBond acceptors 17
HBond donors 5
Atoms 97

Expert Reviews

by SERP
(on 30 Jan 2025 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 5 Feb 2025 )
Cellular Use Rating
alphaSyn PROTAC 2b is a CRBN dependent degrader of alpha-synuclein (aSyn) with single digit micromolar potency and adequate selectivity in both in vitro (HEK293T and SH-SY5Y seeded with aSyn fibrils) and...
by SERP
(on 20 Feb 2025 )
Cellular Use Rating
The Probe is a good tool to examinate facts about alphaSyn aggregates and their degradation. The DC50 and Kd values are relatively high, suggesting weaker binding affinity. However, Figure 3 indicates...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria