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AKR1C3-PROTAC-5 | AKR1C3-PROTAC-5 : Degrader (PROTAC) of AKR1C3 and AR
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
AKR1C3
  • IC50:77.7 nM
  • DC50:52 nM
  • Dmax:75%
AR (Other variant:splicing variant 7)
    • DC50:70 nM
    Degrader (PROTAC)
    10 nM, up to 100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    PROTAC 5 provided a trend of degradation of AKR1C1/C2 in a time-dependent manner, but to a lesser ex ...

    Potency
    Cellular
    In Vitro

    AKR1C3

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1038/s42004-024-01177-4

    AR (Other variant:splicing variant 7)

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1038/s42004-024-01177-4

    Chemical Information

    Molecular Formula C45H43N7O10
    SMILEs O=C(O)/C=C/c1cc(C(=O)NCc2ccc(OCc3cn(CCOCCOCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)nn3)cc2)cc(-c2ccccc2)c1
    InChI InChI=1S/C45H43N7O10/c53-40-15-14-39(44(58)48-40)52-26-37-36(45(52)59)7-4-8-38(37)47-41(54)28-61-20-19-60-18-17-51-25-34(49-50-51)27-62-35-12-9-29(10-13-35)24-46-43(57)33-22-30(11-16-42(55)56)21-32(23-33)31-5-2-1-3-6-31/h1-13,16,21-23,25,39H,14-15,17-20,24,26-28H2,(H,46,57)(H,47,54)(H,55,56)(H,48,53,58)/b16-11+
    Molecular weight 841.31 Da
    AlogP 3.9848000000000026
    HBond acceptors 17
    HBond donors 4
    Atoms 105

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    Expert Reviews

    by SERP+
    (on 31 Oct 2024 )
    Cellular Use Rating
    Results from this can be used as orthogonal tool to validate with more specific genetic knockdown approaches, but cellular selectivity data and/or proteomic data are missing.
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria