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AK-42 | AK-42 : Inhibitor of CLCN2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CLCN2
    • IC50:17 nM
    • INH:2.5 µM
    Inhibitor
    1 µM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    AK-42 displays unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and ex ...

    Potency
    Cellular
    In Vitro

    CLCN2

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1073/pnas.2009977117

    Negative Control Compounds

    2-(3-benzyloxy-2,6-dichloro-anilino)benzoic acid
    Notes: AK-24 IC50 1200 nM

    Chemical Information

    Molecular Formula C19H14Cl2N2O3
    SMILEs O=C(O)c1cccnc1Nc1c(Cl)ccc(OCc2ccccc2)c1Cl
    InChI InChI=1S/C19H14Cl2N2O3/c20-14-8-9-15(26-11-12-5-2-1-3-6-12)16(21)17(14)23-18-13(19(24)25)7-4-10-22-18/h1-10H,11H2,(H,22,23)(H,24,25)
    Molecular weight 388.04 Da
    AlogP 0.0
    HBond acceptors 5
    HBond donors 2
    Atoms 40

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    Expert Reviews

    by SERP
    (on 20 Mar 2026 )
    Cellular Use Rating
    High selectivity of AK-42 >1000 against CLC-1 and selective against a 61 off-targets typically expressed in brain. No biophysical confirmation, but supportive evidence from mutational studies for a computationally...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria