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AK-1690 | AK-1690 : Degrader (PROTAC) of STAT6
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STAT6
    • DC50:1 nM
    • DC50:80 nM
    Degrader (PROTAC)
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    AK-1690 had no significant effect on STAT1, STAT3, STAT5, and pSTAT5Y694 up to 10 μM. AK-1690 had a ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Degradation selectivity of AK-1690 was evaluated on a global level by proteomics. Human PBMCs were t ...
    Selectivity Assessment Description:
    With 18 h treatment at 5 μM, AK-1690 reduced the levels of only four proteins by ≥50% out of >6,000 ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Western blot analysis of Jurkat cells treated with 10 uM AK-1690 has no effect on cereblon neo-subst ...

    Potency
    Cellular
    In Vitro

    STAT6

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/acs.jmedchem.4c01009

    Negative Control Compounds

    AK-1690me
    Notes: AK-1690Me is the negative control, and it does not degrade STAT6
    SMILES: CC(C)([C@@H](C(N1C[C@H](C[C@H]1C(N2CCO[C@@H](C2)c3ccccc3)=O)OCCCCCC#Cc4c(CN(C5=O)[C@@H]6CCC(N(C)C6=O)=O)c5ccc4)=O)NC(c(c7)sc8c7cc(C(F)(P(O)(O)=O)F)cc8)=O)C

    Chemical Information

    Molecular Formula C51H56F2N5O11PS
    SMILEs CC(C)(C)[C@H](NC(=O)c1cc2cc(C(F)(F)P(=O)(O)O)ccc2s1)C(=O)N1C[C@@H](OCCCCCC#Cc2cccc3c2CN([C@@H]2CCC(=O)NC2=O)C3=O)C[C@H]1C(=O)N1CCO[C@H](c2ccccc2)C1
    InChI InChI=1S/C51H56F2N5O11PS/c1-50(2,3)44(55-46(61)42-26-33-25-34(18-20-41(33)71-42)51(52,53)70(65,66)67)49(64)57-28-35(27-39(57)48(63)56-22-24-69-40(30-56)32-14-9-7-10-15-32)68-23-11-6-4-5-8-13-31-16-12-17-36-37(31)29-58(47(36)62)38-19-21-43(59)54-45(38)60/h7,9-10,12,14-18,20,25-26,35,38-40,44H,4-6,11,19,21-24,27-30H2,1-3H3,(H,55,61)(H,54,59,60)(H2,65,66,67)/t35-,38+,39-,40-,44+/m0/s1
    Molecular weight 1015.34 Da
    AlogP 6.232100000000006
    HBond acceptors 16
    HBond donors 4
    Atoms 127

    Expert Reviews

    by SERP
    (on 8 Jan 2026 )
    Cellular Use Rating
    AK-1690 is a selective STAT6 PROTAC degrader with robust cellular characterization. Target engagement is supported by nanomolar degradation potency, an inactive control analog (AK-1690Me), and competition...
    by SERP+
    (on 6 Feb 2026 )
    Cellular Use Rating
    AK-1690 is a degrader with good potency across different cell lines and the time points tested. No hook effect was observed for doses up to 10 uM. There is a negative control compound, AK-1690Me. The probe...
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