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AH078 | AH078 : Degrader (PROTAC) of CSNK1D, CSNK1E
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CSNK1D
    • EC50:3.2 ± 0.2 nM
    • Dmax:70.1%
    • DC50:550 nM
    • Activity:1 µM
    CSNK1E
      • Activity:1 µM
      Degrader (PROTAC)
      1 µM

      Selectivity

      In Cell Selectivity Assessment
      Potency Assay Off-Target:
      Selectivity within target family: AH078 is not able to degrade CK1a at low concentrations (Dmax 35%) ...

      Potency
      Cellular
      In Vitro

      CSNK1D

      Mode of Action: Degrader (PROTAC)

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/acs.jmedchem.4c02201

      CSNK1E

      Mode of Action: Degrader (PROTAC)

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/acs.jmedchem.4c02201

      Negative Control Compounds

      canSAR7437542
      Notes: cpd38 is the S stereoisomer, is able to engage the targets in cell but does not degrade CK1d and CK1e

      Chemical Information

      Molecular Formula C51H60F2N10O5S
      SMILEs Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCC(=O)N2CCC(F)(Cn3cnc(-c4ccc(F)cn4)c3-c3ccnc4[nH]ccc34)CC2)C(C)(C)C)cc1
      InChI InChI=1S/C51H60F2N10O5S/c1-32-45(69-31-59-32)34-13-11-33(12-14-34)26-57-48(67)40-25-36(64)28-63(40)49(68)46(50(2,3)4)60-41(65)9-7-5-6-8-10-42(66)61-23-19-51(53,20-24-61)29-62-30-58-43(39-16-15-35(52)27-56-39)44(62)37-17-21-54-47-38(37)18-22-55-47/h11-18,21-22,27,30-31,36,40,46,64H,5-10,19-20,23-26,28-29H2,1-4H3,(H,54,55)(H,57,67)(H,60,65)/t36-,40+,46-/m1/s1
      Molecular weight 962.44 Da
      AlogP 7.539820000000007
      HBond acceptors 15
      HBond donors 4
      Atoms 129

      References

      Publications

      Cross References

      Expert Reviews

      by SERP+
      (on 6 Feb 2026 )
      Cellular Use Rating
      This probe has been well characterised for degradation of CKIdelta and CKIepsilon, with biochemical experiments and proteomics demonstrating selectivity over other members of the family, including CKIalpha,...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria