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ADL-5747 | ADL-5747 : Agonist of OPRD1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OPRD1
    • Ki:2.7 nM
    • EC50:94 nM
    Agonist
    up to 10 uM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Within Target family: Selective against mu (μ), kappa (κ) receptor Outside target family: Evaluate ...

    Potency
    Cellular
    In Vitro

    OPRD1

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/jm900773n

    In Vivo Validations

    Rat
    Dose: 2.5 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 5.3 h
    Systemic clearance: 3.3 L/h/Kg
    Area Under the Curve:: 780 ng*h/mL
    Volume of Distribution at Steady-State: 18.1 L/Kg

    DOI Reference: 10.1021/jm900773n

    Dose: 10 mg/Kg
    Route of delivery: Oral
    Plasma half life: 4.9 h
    Cmax: 246 ng/mL
    Tmax: 1.3 h
    Area Under the Curve:: 1152 ng*h/mL
    Bioavailability: 37.6%

    DOI Reference: 10.1021/jm900773n

    Dog
    Dose: 1.0 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 12.2 h
    Systemic clearance: 0.38 L/h/Kg
    Area Under the Curve:: 2637 ng*h/mL
    Volume of Distribution at Steady-State: 5.1 L/Kg

    DOI Reference: 10.1021/jm900773n

    Dose: 3.0 mg/Kg
    Route of delivery: Oral
    Plasma half life: 7.7 h
    Cmax: 852 ng/mL
    Tmax: 0.4 h
    Area Under the Curve:: 4203 ng*h/mL
    Bioavailability: 54.5%

    DOI Reference: 10.1021/jm900773n

    Chemical Information

    Molecular Formula C24H28N2O3
    SMILEs CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)c(O)c1
    InChI InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)17-9-10-18(21(27)15-17)20-16-24(11-13-25-14-12-24)29-22-8-6-5-7-19(20)22/h5-10,15-16,25,27H,3-4,11-14H2,1-2H3
    Molecular weight 392.21 Da
    AlogP 3.8205000000000027
    HBond acceptors 5
    HBond donors 2
    Atoms 57

    References

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    Expert Reviews

    by SERP
    (on 21 Oct 2022 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
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