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ABT-724 | Agonist of DRD4
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
DRD4
  • Ki:46.8 - 63.6 nM
  • EC50:12.5 nM
Agonist
10-10000 nM

Selectivity

In Cell Selectivity Assessment
Selectivity Assessment Description:
No activity up to 10 µM for hDRD2 Closest hit in CEREP panel at 10 µM: HTR1A with Ki=2780 nM (73% in ...

Potency
Cellular
In Vitro

DRD4

Mode of Action: Agonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1073/pnas.0308292101

In Vivo Validations

Rat
Dose: 0.03 umol/Kg
Route of delivery: Subcutaneous

DOI Reference: 10.1021/jm030505a

Negative Control Compounds

A-769
Notes: inactive up to10 µM against hDRD4.4 (cellular FLIPR assay)

Chemical Information

Molecular Formula C17H19N5
SMILEs c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1
InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)
Molecular weight 293.16 Da
AlogP 2.2801
HBond acceptors 5
HBond donors 1
Atoms 41

Vendors

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Expert Reviews

No SERP comments found for ABT-724

Probe ABT-724 is in the process of SERP review.

Please continue to check back for new reviews and commentary.