Chemical Probes logo
ABT-100 | Inhibitor of FNTB
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FNTB
  • IC50:0.05 nM
  • EC50:0.73 nM
Inhibitor
10-1000 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
>100 000-fold selective for FNTB over the closely related enzyme PGGT1B (GGTase I)
In Cell Selectivity Assessment
Selectivity Assessment Description:
No activity in panel of 75 off-targets @10 µM; closest hit: phencyclidine PCP receptor IC50 = 3 μ ...

Potency
Cellular
In Vitro

FNTB

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Rat, Dog
Dose: 5 mg/kg (Rat), 2.5 mg/kg (Dog), up to 25 mg/kg (PO)
Route of delivery: Intravenous, Oral
Plasma half life: 2.3 h (Rat), 6.8 h (Dog)
Systemic clearance: 1.2 (Rat) and 0.34 (Dog) l/h/kg

Reference: --

Negative Control Compounds

ABT-108

Chemical Information

Molecular Formula C27H19F3N4O3
SMILEs Cn1cncc1[C@](O)(COc1ccc(C#N)cc1-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)cc1
InChI InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1
Molecular weight 504.14 Da
AlogP 5.043960000000004
HBond acceptors 7
HBond donors 1
Atoms 56

References

Publications

    Cross References

    canSARChEMBLSGC additional analysis

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    by SERP
    (on 4 Jun 2020 )
    Cellular Use Rating
    In Model Organisms
    ABT-100 has been investigated as a novel farnesyltransferase inhibitor in vitro and in vivo. ABT-100 is a highly potent (IC50 = 0.05 nmol/L) inhibitor of the farnesyltransferase and displays >100,000-fold...
    by SERP
    (on 24 Nov 2020 )
    Cellular Use Rating
    In Model Organisms
    ABT-100 appears to be a potent and selective probe compound for the investigation of FNTB biology. Selectivity against the closest related target appears good, though there are little data in the...

    Portal Comments

    In a 2023 study, Hu et al. evaluated ABT-100 in live-cell assays for Phospholipidosis induction, cautioning about adverse effects at concentrations near 1 uM. (DOI: 10.1016/j.chembiol.2023.09.003)

    (last updated: 7 Nov 2023)

    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria