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ABD957 | Covalent Inhibitor of ABHD17B
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ABHD17B
  • IC50:210 nM ABHD17B
  • EC50:29 nM
Covalent Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
LYPLA1 IC50 10 uM in cell lysate
In Cell Selectivity Assessment
Selectivity Assessment Description:
MS-ABPP data for ABD957 (500 nM, 2 h) in OCI-AML3 cells confirmed ABHD17A/B/C inhibition and sele ...

Potency
Cellular
In Vitro

ABHD17B

Mode of Action: Covalent Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-021-00785-8

Negative Control Compounds

ABD298
JJH254

Chemical Information

Molecular Formula C27H36F3N7O5S
SMILEs C[C@H]1CN(Cc2ccc(C(F)(F)F)cc2N2[C@H]3CC[C@@H]2CN(CC(=O)O)C3)CCN1C(=O)n1ccc(S(=O)(=O)N(C)C)n1
InChI InChI=1S/C27H36F3N7O5S/c1-18-13-33(10-11-35(18)26(40)36-9-8-24(31-36)43(41,42)32(2)3)14-19-4-5-20(27(28,29)30)12-23(19)37-21-6-7-22(37)16-34(15-21)17-25(38)39/h4-5,8-9,12,18,21-22H,6-7,10-11,13-17H2,1-3H3,(H,38,39)/t18-,21-,22+/m0/s1
Molecular weight 627.25 Da
AlogP 0.0
HBond acceptors 12
HBond donors 1
Atoms 79

References

Publications

Cross References

canSARPubMed

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Expert Reviews

by SERP
(on 8 Apr 2025 )
Cellular Use Rating
ABD957 is a covalent inhibitor of several serine hydrolases. Activity-based proteomics confirmed inhibition of ABHD17A/B/C and other targets including CES2, ABHD6, CES1 and ABHD13. Please note that due...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria