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AB680 | AB680 : Reversible Competitive Inhibitor of NT5E
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
NT5E
  • Ki, IC50:5 pM, 43 pM
  • IC50:8 pM hCD8+ T; 11 pM hPBMC
Inhibitor
0.4–4 nM
200 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
No off-target activity against the ecto-nucleotidases NTPDase-1 (CD39), -2, -3, and -8 up to 10 µM
In Cell Selectivity Assessment
Potency Assay Off-Target:
CEREP
Selectivity Assessment Description:
Screened against 60 targets in a wide ligand profile screen (CEREP) with no off-target activity obse ...

Potency
Cellular
In Vitro

NT5E

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse, Rat, Dog, Donkey, Human (projected)
Dose: 0.5 mg/Kg, 16 mg/Kg, 25 mg/Kg
Route of delivery: Intravenous
Plasma half life: 3.5(m), 5.3(R), 22(D), 27(M), 98(H) h
Systemic clearance: 25(m), 20(R), 50(D), 0.25(M), 0.12(H) mL/h/Kg

Reference: --

Chemical Information

Molecular Formula C20H24ClFN4O9P2
SMILEs C[C@H](Nc1cc(Cl)nc2c1cnn2[C@@H]1O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O)c1ccccc1F
InChI InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1
Molecular weight 580.07 Da
AlogP 2.353300000000001
HBond acceptors 13
HBond donors 6
Atoms 61

Vendors

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Expert Reviews

by SERP
(on 10 Aug 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 10 Aug 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 5 Sept 2020)
Cellular Use Rating
In Model Organisms
High levels of adenosine with the tumor microenvironment inhibit the activation of T cells and NK cells thereby suppressing the immune function. CD73 is ecto-nucleotidase which catalyses the conversion...
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