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AB680 | AB680 : Reversible Competitive Inhibitor of NT5E
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NT5E
  • Ki, IC50:5 pM, 43 pM
  • IC50:8 pM hCD8+ T; 11 pM hPBMC
Inhibitor
0.4–4 nM
200 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
No off-target activity against the ecto-nucleotidases NTPDase-1 (CD39), -2, -3, and -8 up to 10 µM
In Cell Selectivity Assessment
Potency Assay Off-Target:
CEREP
Selectivity Assessment Description:
Screened against 60 targets in a wide ligand profile screen (CEREP) with no off-target activity obse ...

Potency
Cellular
In Vitro

NT5E

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse, Rat, Dog, Donkey, Human (projected)
Dose: 0.5 mg/Kg, 16 mg/Kg, 25 mg/Kg
Route of delivery: Intravenous
Plasma half life: 3.5(m), 5.3(R), 22(D), 27(M), 98(H) h
Systemic clearance: 25(m), 20(R), 50(D), 0.25(M), 0.12(H) mL/h/Kg

Reference: --

Chemical Information

Molecular Formula C20H24ClFN4O9P2
SMILEs C[C@H](Nc1cc(Cl)nc2c1cnn2[C@@H]1O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O)c1ccccc1F
InChI InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1
Molecular weight 580.07 Da
AlogP 2.353300000000001
HBond acceptors 13
HBond donors 6
Atoms 61

References

Publications

    Cross References

    canSARChEMBLBindingDBPDBPubMed

    Vendors

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    Expert Reviews

    by SERP
    (on 10 Aug 2020 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 10 Aug 2020 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 5 Sept 2020 )
    Cellular Use Rating
    In Model Organisms
    High levels of adenosine with the tumor microenvironment inhibit the activation of T cells and NK cells thereby suppressing the immune function. CD73 is ecto-nucleotidase which catalyses the conversion...
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