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A-192621 | A-192621 : Antagonist of EDNRB
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EDNRB
  • Ki:8.8 nM
  • IC50:4.5 nM
  • IC50:0.8 nM
Antagonist
in some publications a dose of 30 mg/kg/d in mouse and rat has been used
0-300 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family: Surpasses criterion: > 600-fold selective against EDNRA (IC50 for ...

Potency
Cellular
In Vitro

EDNRB

Mode of Action: Antagonist

Structure-Activity-Relationship data available? No

DOI Reference: 10.1042/CS103S107S

In Vivo Validations

Rat
Dose: 5 mg/Kg IV, 10 mg/Kg PO
Route of delivery: Intravenous, oral
Plasma half life: 5h PO
Cmax: 0.81 ug/mL
Area Under the Curve:: 3.60 IV, 2.51 PO µg*h/mL
Bioavailability: 34.9%

DOI Reference: 10.1042/CS103S112S

Dog
Dose: 5 mg/Kg IV, 10 mg/Kg PO
Route of delivery: Intravenous, Oral
Plasma half life: 2h PO
Cmax: 0.38 ug/mL
Area Under the Curve:: 4.07 (IV), 0.45 (PO) µg*h/mL
Bioavailability: 11%

DOI Reference: 10.1042/CS103S112S

Monkey (Cynomolgus)
Dose: 5 mg/Kg IV, 10 mg/Kg PO
Plasma half life: 3.1 h
Cmax: 0.19 ug/mL
Area Under the Curve:: 5.25 (IV), 0.68 (PO) µg*h/mL
Bioavailability: 13%

DOI Reference: 10.1042/CS103S112S

Negative Control Compounds

A-1806262
Notes: The control enantiomer A-1806262 is about 150-fold selective compared to probe.

Chemical Information

Molecular Formula C33H38N2O6
SMILEs CCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1
InChI InChI=1S/C33H38N2O6/c1-4-16-39-25-13-10-23(11-14-25)32-30(33(37)38)26(24-12-15-27-28(17-24)41-20-40-27)18-35(32)19-29(36)34-31-21(5-2)8-7-9-22(31)6-3/h7-15,17,26,30,32H,4-6,16,18-20H2,1-3H3,(H,34,36)(H,37,38)/t26-,30-,32+/m1/s1
Molecular weight 558.27 Da
AlogP 5.8089
HBond acceptors 8
HBond donors 2
Atoms 79

Vendors

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Expert Reviews

by SERP
(on 13 Feb 2022)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
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