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A-1211212 | Inhibitor of BCL2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BCL2
  • IC50:1.4 nM
  • EC50:6 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family: BCL2L1: IC50 = 753 nM (TR-FRET); MCL1: IC50 = 2050 nM (TR-FRET). S ...

Potency
Cellular
In Vitro

BCL2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1126/scitranslmed.aaa4642

In Vivo Validations

Mouse
Dose: 50 mg/Kg/day
Organ of interest (O): Xenograft

DOI Reference: 10.1126/scitranslmed.aaa4642

Negative Control Compounds

A-1210227
Notes: A-1210227 >100- fold less potent in binding and cellular assays (BCL2: IC50 = 296 nM (TR-FRET)) Closest off-target in the GPCR (43) scan is TMEM97 (Ki = 8371.44 nM).

Orthogonal Probes def

VENETOCLAX

Chemical Information

Molecular Formula C47H54ClN7O7S
SMILEs CO[C@H]1CC[C@H](CNc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CC(C)(C)CC5)CC4)cc3Oc3cnc4[nH]ccc4c3)cc2[N+](=O)[O-])CC1
InChI InChI=1S/C47H54ClN7O7S/c1-47(2)18-16-34(41(27-47)32-6-8-35(48)9-7-32)30-53-20-22-54(23-21-53)36-10-14-40(44(25-36)62-38-24-33-17-19-49-45(33)51-29-38)46(56)52-63(59,60)39-13-15-42(43(26-39)55(57)58)50-28-31-4-11-37(61-3)12-5-31/h6-10,13-15,17,19,24-26,29,31,37,50H,4-5,11-12,16,18,20-23,27-28,30H2,1-3H3,(H,49,51)(H,52,56)/t31-,37-
Molecular weight 895.35 Da
AlogP 9.4385
HBond acceptors 14
HBond donors 3
Atoms 117

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Expert Reviews

No SERP comments found for A-1211212

Probe A-1211212 is in the process of SERP review.

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