Chemical Probes logo
A-1155463 | A-1155463 : BH3 mimetic inhibitor of BCL2L1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BCL2L1
  • Ki:<0.01 nM
  • EC50:8 nm
BH3 mimetic
50-500 nM

Selectivity

In Vitro Selectivity Assessment

Potency: Ki - BCL2: 80 nM, BCLW: 19 nM, MCL1: >440 nM

Potency Assay Off-Target:
TR-FRET assays

Potency
Cellular
In Vitro

BCL2L1

Mode of Action: BH3 mimetic

Structure-Activity-Relationship data available? No

In Vivo Validations

SCID beige mice
Dose: 5 mg/kg
Route of delivery: Intraperitoneal
Organ of interest (O): Platelets, tumor xenografts
Target engagement assay: In mice treated with A1155463, platelet counts declined within 6 hours of dosing and rebounded by 72 hours. In mice with H146 tumor xenografts, A1155463 inhibited tumor growth.

Reference: --

Orthogonal Probes def

DT-2216
WEHI-539
A-1331852

Chemical Information

Molecular Formula C35H32FN5O4S2
SMILEs CN(C)CC#Cc1ccc(OCCCc2sc(N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)nc2C(=O)O)c(F)c1
InChI InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
Molecular weight 669.19 Da
AlogP 6.3298
HBond acceptors 9
HBond donors 2
Atoms 79

References

Publications

    Cross References

    canSARChEMBLBindingDBPDBe (Protein Data Bank Europe)

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    by SERP
    (on 25 Apr 2017 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 19 May 2017 )
    Cellular Use Rating
    In Model Organisms
    This is a very promising probe.
    by SERP
    (on 12 Jun 2017 )
    Cellular Use Rating
    In Model Organisms
    This probe is a selective picomolar inhibitor of BCL-XL. I recommend to use this probe to interrogate BCL-XL target in cells. It should be used in combination with ABT-199 (a selective inhibitor of...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria